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PMCID: PMC7600128
Most patients have mild skin reactions, while severe (grade 3-4) toxicities are found in a low proportion of patients (5.8% for the ipilimumab + nivolumab combination, even lower values for anti-PD-1 monotherapy), significantly lower than the toxicities of other sites (such as hepatic or gastrointestinal) (129)
Often referred to informally as the Wolverine peptide, this nickname reflects how researchers and science commentators describe its association with tissue related research models, not a scientific classification or medical claim
Close supervision by a skilled healthcare provider helps to mitigate these potential risks
It was cloned for the first time using the Neh2 domain of NRF2 as bait in a yeast two-hybrid system by Yamamoto and coworkers [118]
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